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Common triggers include alcohol, spicy foods, insect stings and certain medications. Mast cells (MCs) are cells that play an important role in your immune system, telling your body when to respond to things that shouldn’t be there. Zyflo®/Zyflo CR® … How mast cells can cause muscle and joint pain. Omalizumab (which blocks binding of IgE to its receptors) has been reported to reduce mast cell reactivity and sensitivity to activation which can reduce anaphylactic episodes. Second generation antihistamines, including loratadine, cetirizine and fexofenadine, are preferable due to fewer side effects. Singulair® Montelukast. 2018; doi:10.1111/bjh.14967. Novel approaches for systemic mastocytosis. Symptoms include episodes of abdominal pain, cramping, diarrhea, flushing, itching, wheezing, coughing, lightheadedness and potential problems with "brain fog" or other difficulties with memory. The episodes are called “idiopathic” which means that the mechanism is unknown - that is, not caused by allergic antibody or secondary to other known conditions that activate normal mast cells. Cutaneous: This type of mastocytosis affects the skin only. Coltoff A, et al. MCAS … In allergic reactions, this release occurs when the allergy antibody IgE, which is present on the mast cell surfaces, binds to proteins that cause allergies, called allergens. High levels of mast cell mediators are released during those episodes. Mast cells are best known for the role they play in allergic and anaphylactic response. Mast cells are found in connective tissues throughout your body. Thank you for your research. Mastocytosis. Antihistamines, such as the first generation histamine type 1 receptor blockers diphenhydramine and hydroxyzine, can be effective for itching, abdominal discomfort and flushing, but their use may be limited by side effects (sleepiness). Genetic and Rare Diseases Information Center. A new therapy to calm down mast cells »